PROTECTIVE POTENTIAL OF 17-β-ESTRADIOL ON OXIDATIVE STRESS AND RENAL METABOLISM IN AGED FEMALE RATS

Abstract Background and Aims The objective of this study was to observe the changes in activity antioxidant enzymes, hepatic glucose homeostasis, lipogenic enzymes lipid metabolism, serum profile liver function occurring livers female rats 3, 12 24 months age groups, see whether these are restored 3 control levels after exogenous administration steroid hormone estrogens (17-β-estradiol, E2). Methods aged (12 old) (n= 8 for each group) were given subcutaneous injection 17beta estradiol (0.1 ug/g body weight) daily one month. After 30 days treatment, experimental animals all groups sacrificed isolated further study. A detailed carried on non-enzymatic glutathione (GSH) enzymatic antioxidants [superoxide dismutase (SOD), peroxidase (GPX) catalase (CAT)], aspartate aminotransferase (GOT), alanine (GPT),alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), alkalin (PAL) as well bilirubin level. Results results obtained present work revealed that normal aging associated with significant decrease activities expression an increase GGT, PAL, GOT, GPT, ALP level increased significantly rats. Our data showed E2 brought near normalcy Conclusions treatment reversed levels. may be beneficial preventing some related by increasing defences oxidative stress. plays important role progression chronic diseases.